FACULTY OF ARTS AND SCIENCESDEPARTMENT OF BIOLOGICAL SCIENCES: BIOLOGY/MOLECULAR BIOLOGY & GENETICS


Faculty

Prof. Dr. Emel ARINÇ

Middle East Technical University, Department of Biological Sciences, 06800 Ankara/TURKEY

Office Room: 223

Tel: +90 312 210 6478

Fax: +90 312 210 7976

E - Mail: earinc[-at-]metu.edu.tr

Web:

Education: B.Sc. and M.Sc. in Chemical Engineering İstanbul University; M.Sc. in Biochemistry North Carolina State University; Ph.D. in Biochemistry North Carolina State University; Post Doctoral Fellow at National Institutes of Environmental Health Sciences/NIH Molecular Pharmacology Branch


Research Interest: Biochemistry and Molecular Biology, Molecular Pharmacology and Toxicology, Cancer Pharmacogenomics, Biotechnology, Ecotoxicology


Description of research activities:


Selected Publications:

Arinç, E.,Tumer, T. B.; Gurses, S.; Ulusoy, G.: Pharmacogenetics of thiopurine methyltransferase in treatment of acute lymphoblastic leukemia with 6-mercaptopurine in Turkish children. Pediatric Oncology and Cancer, 60, S3, 55-56, 2013.

Çelik, H., Kosar, M., and Arinç, E.: In vitro effects of myricetin, morin, apigenin, (+)-taxifolin, (+)-catechin, (-)-epicatechin, naringenin and naringin on cytochrome b5 reduction by purified NADH-cytochrome b5 reductase. Toxicology, 308, 34-40, 2013.

Çelik, H., and Arinç, E.: Evaluation of bioreductive activation of anticancer drugs idarubicin and mitomycin C by NADH -cytochrome b5 reductase and cytochrome P4502B4. Xenobiotica, 43 (3), 263-275, 2013.

Tumer, T.B., Sahin, G., Arinç, E. : Association between polymorphisms of EPHX1 and XRCC1 genes and the risk of childhood acute lymphoblastic leukemia. Archives of Toxicology,  86 (3), 431-439, 2012.

Sen, A., Ozgun, O., Arinç, E., and Arslan, S.:  Diverse action of acrylamide on cytochrome P450 and glutathione S-transferase isozyme activities, mRNA levels and protein levels in human hepatocarcinoma cells. Cell Biology and Toxicology,  28 (3), 175-186, 2012.

Tumer, T.B., Yilmaz, D., Tanrikut, C., Sahin, G., Ulusoy, G., Arinç, E. : DNA repair XRCC1 Arg399Gln polymorphism alone, and in combination with CYP2E1 polymorphisms significantly contribute to the risk of development of childhood acute lymphoblastic leukemia. Leukemia Research, 34 (10) ,  1275-1281, 2010.

Çelik, H. and Arinç, E.: Evaluation of the protective effects of quercetin, resveratrol, naringenin, rutin and trolox against idarubicin-induced DNA damage. Journal of Pharmacy and Pharmaceutical Sciences, 13 (2), 231-241, 2010.

Arinç, E.: The role of polymorphic cytochrome P450 enzymes in drug design, development and drug interactions with special emphasis on phenotyping. Journal of Molecular Catalysis B: Enzymatic, 64 (3-4), 120-122, 2010.

Bozcaarmutlu, A., Sapmaz, C., Aygun, Z., and Arinç, E., : Assessment of pollution in the West Black Sea Coast of Turkey using biomarker responses in fish. Marine Environmental Research, 67 (4-5):167-176, 2009.

Çelik H., and Arinç, E. : Bioreduction of Idarubicin and Formation of ROS Responsible for DNA
Cleavage by NADPH-Cytochrome P450 Reductase and its Potential Role in the Antitumor Effect.
Journal of Pharmacy and Pharmaceutical Sciences, 11 (4): 68-82, 2008.

Tümer, T. B, G. Ulusoy,G., Adalı, O., G. Şahin, G., Gözdaşoğlu, S., Arınç, E.:The low frequency of defective TPMT alleles in Turkish Population: A study on pediatric patients with acute lymphoblastic leukemia. American Journal of Hematology, 82(10), 906-910, 2007.

Ulusoy, G., Adali, O., Tümer, T.B, Sahin, G., Gözdaşoğlu, S., E. Arinç, E.: Significance of genetic polymorphisms at multiple loci of CYP2E1 in the risk of development of childhood acute lymphoblastic leukemia. Oncology, 72(1-2), 125-131, 2007.

Arinç, E., Arslan, S., Bozcaarmutlu, A. and Adalı, O.: Effects of diabetes on rabbit kidney and lung CYP2E1 and CYP2B4 expression and drug metabolism and potentiation of carcinogenic activity of N-nitrosodimethylamine in kidney and lung. Food and Chemical Toxicology, 45(1), 105-118, 2007.

Bozcaarmutlu, A. and Arinç, E.: Inhibitory effects of divalent metal ions on liver microsomal 7-ethoxyresorufin O-deethylase (EROD) activity of leaping mullet. Marine Environmental Research, 58, 521-524, 2004.


Arinç E., and Bozcaarmutlu, A.: Catalyzation of Cocaine N-demethylation by cytochromes P4502B, P4503A, and P4502D in Fish Liver. Journal of Biochemical and Molecular Toxicology, 17, 169-176, 2003.

Şen, A., Hu, C-H, Urbach, E., Wang-Buhler, J-L., Yang, Y-H., Arinç, E., and Buhler, D. R.: Cloning, sequencing and characterization of CYP1A1 cDNA from Leaping Mullet (Liza Saliens) liver and implications for the potential functions of its conserved amino acids. Journal of Biochemical and Molecular Toxicology, 15 (No.5), 243-255, 2001.

Arinç, E., Kocabıyık, S., and Su, E.: Induced CYP mRNA, protein and catalytic activity in the liver of feral fish, leaping mullet, Lisa saliens. Comparative Biochemistry and Physiology C. Pharmacology, Toxicology and Endocrinology, 128C (2) 281-290, 2001.

Şen, A. and Arinç, E.: Further immunochemical and biocatalytic characterization of CYP1A1 from feral leaping mullet liver (Liza saliens) microsomes. Comparative Biochemistry and Physiology C. Pharmacology, Toxicology and Endocrinology, 126C (3), 235-244, 2000.

Arinç, E., Şen, A., and Bozcaarmutlu, A.: Cytochrome P4501A and associated MFO induction in fish as a biomarker for toxic, carcinogenic pollutants in the aquatic environment. Pure and Applied Chemistry, 72 (6) (June issue), 985-994, 2000.

Arinç, E., and Şen, A.:Hepatic Cytochrome P4501A1 and 7-Ethoxyresorufin O-deethylase induction in Mullet and Common Sole as an indicator of toxic organic pollution in İzmir Bay, Turkey. Marine Environmental Research, 48, 147-160, 1999.

Şen, A. and Arinç, E.: Preparation of highly purified cytochrome P4501A1 from leaping mullet (Liza saliens) liver microsomes and its biocatalytic, molecular and immunological properties. Comparative Biochemistry and Physiology Part C, 121C, 249-265, 1998.

Başaran, N. and Arinç, E.: Purification and characterization of two forms of microsomal cytochrome b5 from sheep lung. International Journal of Biochemistry and Cell Biology, 30, 719-734, 1998.

Koziol, C., Batel, R., Arinç, E., Schröder, H.C. and Müller W.E.G.: Expression of the potential biomarker heat shock protein 70 and its regulator, the metazoan DnaJ homolog, by temperature stress in the sponge Geodia cydonium. Marine Ecology Progress Series, 154, 261-268, 1997.

Arinç, E., Hanukoglu, I., Şen, A. and Adalı, O.: Tissue–and-species dependent expression of sheep lung microsomal cytochrome P4502B (LgM2). Biochemistry and Molecular Biology International, 37, 1121-1126, 1995.

Arinç, E., Pasha, R.P., Adalı, O. and Başaran, N.: Stimulatory effects of lung cytochrome b5 on benzphetamine N-demethylation in a reconstituted system containing lung cytochrome P450LgM2. International Journal of Biochemistry, 26, 1033-1042, 1994.

Arinç, E., Adalı, O., İşcan, M. and Güray, T.: Stimulatory effects of benzene on rabbit liver and kidney microsomal cytochrome P-450 drug metabolizing enzymes. Archives of Toxicology, 65, 186-190, 1991.

Güray, T. and Arinç, E.: Purification of NADH-cytochrome b5 reductase from sheep lung and its electrophoretic, spectral and some other properties. International Journal of Biochemistry, 22, 1029-1037, 1990.

İşcan, M.Y. and Arinç, E.: Comparison of highly purified sheep liver and lung NADPH-cytochrome P-450 reductases by the analysis of kinetic and catalytic properties. International Journal of Biochemistry, 20, 1189-1196, 1988.

Arinç, E., Rzepecki, L.M. and Strittmatter, P.: Topography of the C terminus of cytochrome b5 tightly bound to dimyristoylphosphatidylcholine vesicles. The Journal of Biological Chemistry, 262, 15563-15567, 1987.

İşcan, M., Arinç, E., Vural, N. and İşcan, M.Y.: In vivo effects of 3-methylcholanthrene, phenobarbital, pyrethum and 2,4,5-T isooctylester on liver, lung and kidney microsomal mixed-function oxidase system of guines-pig; A comparative study. Comparative Biochemistry and Physiology, 77C, 177-190, 1984.

Arinç, E. and İşcan, MY.: Comparative studies of sheep liver and lung microsomal aniline 4- hydroxylase. Comparative Biochemistry and Physiology, 74C, 151-158, 1983.

Philpot, R.M. and Arinç, E.: Separation and purification of two forms of hepatic cytochrome P-450 from untreated rabbits. Molecular Pharmacology, 12, 483-493, 1976.

Arinç, E. and Philpot, R.M.: Preparation and properties of partially purified pulmonary cytochrome P-450 from rabbits. The Journal of Biological Chemistry, 251, 3213-3220, 1976.

Main, A.R., Soucie, W.G., Buxton, I.L. and Arinç, E.: The purification of cholinestrase from horse serum. The Biochemical Journal, 143, 733-744, 1974.

Main, A.R., Tarkan (Arinç), E., Aull, J.L. and Soucie, W.G.: Purification of horse serum cholinesterase by preparative polyacrylamide gel electrophoresis. The Journal of Biological Chemistry, 247, 566-571, 1972.


Book Chapter :
Arinç, E.:‘Extrahepatic Microsomal Forms: Lung microsomal cytochrome P450 isozymes ‘pp. 373-386. In Schenkman, J. B. and Greim, H. (editors). Handbook of Experimental Pharmacology. Vol. 105, Cytochrome P450. Springer-Verlag, Heidelberg, 1993.


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