Assist. Prof. Dr. Erkan KİRİŞ

Office Room: Z-16

Tel: +90 312 210 5169


E - Mail: ekiris[-at-]metu.edu.tr



Research Interest: Neurobiology of Disease

Description of research activities:

Selected Publications:

1. Y.C. Tsai, A. Kotiya, E. Kiris, M. Yang, S. Bavari, L. Tessarollo, G.A. Oyler, A.M. Weissman (2017). “The deubiquitinating enzyme VCIP135 dictates the duration of botulinum neurotoxin type A intoxication”. Proceedings of the National Academy of Sciences. 114(26):E5158-E5166.
2. M.C. Choi, P. J. Chung, C. Song, H. P. Miller, E. Kiris, Y. Li, L. Wilson, S.C. Feinstein, and C. R. Safinya (2017). “Paclitaxel Suppresses Tau-Mediated Microtubule Bundling”. Biochimica et Biophsica Acta (BBA)-General Subjects, 1861(1 Pt A):3456-3463. doi: 10.1016/j.bbagen.2016.09.011.
3. S. Puverel*, E. Kiris*, S. Singh, K.D. Klarmann, V. Coppola, J. Keller and L. Tessarollo (2016). “RanBPM (RanBP9) regulates mouse c-Kit receptor level and is essential for normal development of bone marrow progenitor cells”. Oncotarget, 2016 Dec 20;7(51):85109-85123. doi: 10.18632/oncotarget.13198. * Equal Contribution.
4. E. Kiris, J. C. Burnett, J. E. Nuss, L. M. Wanner, B. D. Peyser, H. T. Du, G. Y. Gomba, K. P. Kota, R. Panchal, R. Gussio, C.D. Kane, L. Tessarollo, and S. Bavari (2015). “Src family kinase inhibitors antagonize the toxicity of multiple serotypes of Botulinum neurotoxin in human embryonic stem cell-derived motor neurons”. Neurotoxicity Research, 27:384–398, DOI 10.1007/s12640-015-9526-z. *Selected as the cover illustration for the May 2015 edition of the journal.
5. E. Kiris, J. E. Nuss, S. M. Stanford, L. M. Wanner, L. Cazares, M. F. Maestre, H.T. Du, G. Y. Gomba, J. C. Burnett, R. Gussio, N. Bottini, R. Panchal, C. D. Kane, L. Tessarollo, and S. Bavari (2015). “Phosphatase inhibitors function as novel, broad spectrum Botulinum neurotoxin antagonists in mouse and human embryonic stem cell-derived motor neuron-based assays”. PLoS One. 2015 Jun 10;10(6):e0129264. doi: 10.1371/journal.pone.0129264.
6. E. Kiris*, T. Wang*, S. Yanpallewar, S. Dorsey, J. Becker, S. Bavari, M.E. Palko, V. Coppola, and L. Tessarollo (2014). “TrkA in vivo function is negatively regulated by ubiquitination”. The Journal of Neuroscience, Mar 12;34(11):4090-8. doi: 10.1523/JNEUROSCI.4294-13.2014. *Equal Contribution. *Highlighted as a featured article by the journal.
7. E. Kiris, J. E. Nuss, J. C. Burnett, K. P. Kota, D. C. Koh, L. M. Wanner, E. Torres-Melendez, R. Gussio, L. Tessarollo, and S. Bavari (2011). “Embryonic stem cell derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery”. Stem Cell Research, 6, pp 195-205, doi: 10.1016/j.scr.2011.01.002.
8. E. Kiris, D. Ventimiglia, M. R. Gaylord, M.E. Sargin, A. Altinok, K. Rose, B.S. Manjunath, M. A. Jordan, L. Wilson and S. C. Feinstein (2011). “Combinatorial Tau Pseudophosphorylation: Markedly different regulatory effects on microtubule assembly and dynamic instability than the sum of the individual parts”. Journal of Biological Chemistry, 286, 14257-14270, doi: 10.1074/jbc.M111.219311.

Graduate program affiliation: