Middle East Technical University Üniversiteler Mahallesi, Dumlupınar Bulvarı No:1 Biyolojik Bilimler, 136 06800 Çankaya Ankara/TURKEY

Office Room: 136

Tel: 0090 312 210 5165

Web: www.metu.edu.tr

Education: BSc METU, MSc METU, PhD University of London

Research Interest: Innate immunity

Description of Research Activities: Our group is conducting research on mechanisms of innate immune sensing. One major research focus is on strategies to improve the delivery and boost the activity of pattern recognition receptor ligands that would be of interest as vaccine adjuvants. Particularly, we have been testing such adjuvants in murine tumor models and in Leishmaniasis. Another research focus of our lab is to employ Leishmania or bacteria-derived extracellular vesicles as vaccine antigens and/or immunomodulatory agents. Our lab is also interested in primary immunodeficiencies and we are collaborating with clinical immunologists to study the mechanisms contributing to disease pathogenesis in PIDs and autoinflammatory conditions.

Selected Publications: 1. Gul E, Sayar EH, Gungor B, Eroglu FK, Surucu N, Keles S, Guner SN, Fındık S, Alpdündar E, Ayanoglu IC, Kayaoglu B, Geçkin BN, Sanli HA, Kahraman T, Yakicier C, Muftuoglu M, Oguz B, Cagdas Ayvaz DN, Gursel I, Ozen S, Reisli I, Gursel M. Type I IFN related NETosis in Ataxia Telangiectasia and Artemis deficiency. J Allergy Clin Immunol. 2017; pii: S0091-6749(17)31762-1. doi: 10.1016/j.jaci.2017.10.030. 2. Kahraman T, Gucluler G, Simsek I, Yagci FC, Yildirim M, Ozen C, Dinc A, Gursel M, Ikromzoda L, Sutlu T, Gay S, Gursel I. Circulating LL37 targets plasma extracellular vesicles to immune cells and intensifies Behçet's disease severity. J Extracell Vesicles. 2017;6(1):1284449. doi: 10.1080/20013078.2017. 3. Gucluler G, Adiguzel E, Gungor B, Kahraman T, Gursel M, Yilmaz B, Gursel I. Impaired toll like receptor-7 and 9 induced immune activation in chronic spinal cord injured patients contributes to immune dysfunction. PLoS One. 2017; 12(2):e0171003. doi: 10.1371/journal.pone.0171003 4. Bayyurt B, Tincer G, Almacioglu K, Alpdundar E, Gursel M, Gursel I. Encapsulation of two different TLR ligands into liposomes confer protective immunity and prevent tumor development. J Control Release. 2017;247:134-144. doi: 10.1016/j.jconrel.2017.01.004. 5. Gursel M, Gursel I. Development of CpG ODN Based Vaccine Adjuvant Formulations. Methods Mol Biol. 2016;1404:289-98. doi: 10.1007/978-1-4939-3389-1_20. 6. Gungor B, Adiguzel E, Gursel I, Yilmaz B, Gursel M. Intestinal Microbiota in Patients with Spinal Cord Injury. PLoS One. 2016;11(1):e0145878. 7. Yáñez-Mó M, Siljander PR, Andreu Z, Zavec AB, Borràs FE, Buzas EI, Buzas K, Casal E, Cappello F, Carvalho J, Colás E, Cordeiro-da Silva A, Fais S, Falcon-Perez JM, Ghobrial IM, Giebel B, Gimona M, Graner M, Gursel I, Gursel M, Heegaard NH, Hendrix A, Kierulf P, Kokubun K, Kosanovic M, Kralj-Iglic V, Krämer-Albers EM, Laitinen S, Lässer C, Lener T, Ligeti E, Linē A, Lipps G, Llorente A, Lötvall J, Manček-Keber M, Marcilla A, Mittelbrunn M, Nazarenko I, Nolte-'t Hoen EN, Nyman TA, O'Driscoll L, Olivan M, Oliveira C, Pállinger É, Del Portillo HA, Reventós J, Rigau M, Rohde E, Sammar M, Sánchez-Madrid F, Santarém N, Schallmoser K, Ostenfeld MS, Stoorvogel W, Stukelj R, Van der Grein SG, Vasconcelos MH, Wauben MH, De Wever O. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles. 2015; 14;4:27066. doi: 10.3402/jev.v4.27066. 8. Yildiz S, Alpdundar E, Gungor B, Kahraman T, Bayyurt B, Gursel I, Gursel M. Enhanced immunostimulatory activity of cyclic dinucleotides on mouse cells when complexed with a cell-penetrating peptide or combined with CpG. Eur J Immunol. 2015; doi: 10.1002/eji.201445133. 9. Gursel,M. Klinman, D.M. Use of CpG Oligonucleotides as mucosal adjuvants. Mucosal Immunology. 2015 10. Gungor B, Yagci FC, Gursel I, Gursel M. Forging of a Potent Vaccine Adjuvant: CpG ODN/Cationic Peptide Nanorings. Oncoimmunology, 2014; 3(7):e950166. 11. Gungor B, Yagci FC, Tincer G, Bayyurt B, Alpdundar E, Yildiz S, Ozcan M, Gursel I, Gursel M. CpG ODN nanorings induce IFNα from plasmacytoid dendritic cells and demonstrate potent vaccine adjuvant activity. Sci Transl Med. 2014; 6(235):235ra61. (selected as the cover story) 12. M. Gursel, DM. Klinman, I. Gursel, Plasmacytoid dendritic cell responses to CpG ODN correlate with CXCL16 expression levels, Mediators Inflamm, 2013;2013:312590. 13. Enayat S, Ceyhan MS, Başaran AA, Gursel M, Banerjee S, Anticarcinogenic Effects of the Ethanolic Extract of Salix aegyptiaca in Colon Cancer Cells: Involvement of Akt/PKB and MAPK Pathways. Nutr Cancer. 2013 Oct;65(7):1045-58. 14. F. Steinhagen, C. Meyer, D. Tross, M. Gursel, T. Maeda,S. Klaschik, D. M. Klinman, Activation of type I interferon-dependent genes characterizes the “core response” induced by CpG DNA. J. Leuko. Biol.,92: , 2012. 15. E. Erikçi, M. Gürsel, I. Gursel , Differential Immune Activation Following Encapsulation of Immunostimulatory CpG Oligodeoxynucleotide in Nanoliposomes. Biomaterials. 32(6):1715-23, 2011. 16. FC. Yagci, O. Aslan, M. Gursel, G. Tincer, Y. Ozdamar, K. Karatepe, KC. Akcali, I. Gursel, Mammalian telomeric DNA suppresses endotoxin induced uveitis. J Biol Chem. 285:28806, 2010.

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