|Prof. Dr. Mayda Gürsel|
Department of Biological Sciences
Office Room: 136
Fax: +90 312 210 7976
E - Mail: mgursel[-at-]metu.edu.tr
Education: BSc METU, MSc METU, PhD University of London
Research Interest: Innate immunity
Description of research activities: The innate immune system discriminates between “non-infectious self” and “infectious non-self” by sensing “pathogen associated molecular patterns” (PAMPs) expressed by infectious microorganisms. Toll like receptors (TLR) expressed on immune cells recognize PAMPs. This interaction initiates a robust innate immune response that enables the host to control the pathogen’s initial spread and subsequently generate sterilizing adaptive immunity. My research interest focuses on TLR ligands and their therapeutic applications as vaccine adjuvants, immune stimulants and anti-cancer agents.
Steinhagen F, Meyer C, Tross D, Gursel M, Maeda T, Klaschik S, Klinman DM,
Activation of type I interferon-dependent genes characterizes the "core response" induced by CpG DNA. J Leukoc Biol. 2012 Oct;92(4):775-85
E. Erikçi, M. Gürsel, I. Gursel , Differential Immune Activation Following Encapsulation of Immunostimulatory CpG Oligodeoxynucleotide in Nanoliposomes. Biomaterials, 32:1715, 2011.
FC. Yagci, O. Aslan, M. Gursel, G. Tincer, Y. Ozdamar, K. Karatepe, KC. Akcali, I. Gursel, Mammalian telomeric DNA suppresses endotoxin induced uveitis. J Biol Chem. 285:28806, 2010.
M. Gürsel, I. Gursel, HS. Mostowski, DM. Klinman, CXCL16 Influences the Nature and Specificity of CpG-Induced Immune Activation, J. Immunol., 177:1575, 2006.
C. Coban, KJ. Ishii, M. Gürsel, DM. Klinman, N. Kumar, Effect of plasmid backbone modification by different human CpG motifs on the immunogenicity of DNA vaccine vectors, J.Leuko.Biol., 78:647, 2005.
H. Shirota, I. Gursel, M. Gürsel, D. M. Klinman, Suppressive oligodeoxynucleotides protect mice from lethal endotoxic shock, J. Immunol, 174:4579, 2005.
T. Sugiyama, M. Gürsel, F. Takeshita, C. Coban, J. Conover, T. Kaisho, S. Akira, DM. Klinman, CpG RNA: identification of single stranded RNA that stimulates human CD14+CD11c+ monocytes, J. Immunol, 174:2273, 2005.
S. Ito, K.J. Ishii, M. Gürsel, H Shirota, A. Ihata, D. M. Klinman, CpG oligodeoxynucleotides enhance neonatal resistance to listeria infection, J. Immunol, 174:777, 2005.
H. Shirota, M. Gürsel, D. M. Klinman, Suppressive oligodeoxynucleotides inhibit Th1 differentiation by blocking IFNg and IL-12 mediated signaling, J. Immunol,173:5002, 2004.
F. Takeshita, I. Gursel, K.J. Ishii, K. Suzuki, M. Gürsel, D. M. Klinman, Signal transduction pathways mediated by the interaction of CpG DNA with toll-like receptor 9, Semin. Immunol., 16:17, 2004.
K. J. Ishii, I. Gursel, M. Gürsel, D. M. Klinman, Immunotherapeutic utility of stimulatory and suppressive oligodeoxynucleotides., Curr. Op. Mol. Ther. 6:166, 2004.
D. M. Klinman, R.A. Zeuner, H. Yamada, M. Gürsel, D. Currie, I. Gursel, Regulation of CpG-induced immune activation by suppressive oligodeoxynucleotides. Ann. N.Y. Acad. Sci. 1002:112, 2003.
I. Gursel, M. Gürsel, H. Yamada, F. Takeshita, K. J. Ishii, D. M. Klinman, Repetitive elements present in mammalian telomeres suppress CpG DNA induced immune activation, J. Immunol. 171:1393, 2003.
D. Verthelyi, M. Gürsel, RT. Kenney, JD. Lifson, S. Liu, J. Mican, DM. Klinman, CpG Oligodeoxynucleotides Protect Normal and SIV-Infected Macaques from a Leishmania Infection, J. Immunol, 170:4717, 2003.
RA. Zeuner, D. Verthelyi, M. Gürsel, KJ Ishii, and DM Klinman, Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis. Arthritis Rheum., 48:1701, 2003.
RA. Zeuner, DM. Klinman, G. Illei, CH. Yarboro, KJ. Ishii, M. Gürsel, D. Verthelyi. Response of PBMC from lupus patients to stimulation by CpG oligondeoxynucleotides. Rheumatology. 42:563, 2003.
H. Yamada, I. Gursel, F. Takeshita, J. Conover, KJ. Ishii, M. Gürsel, S. Takeshita, and DM. Klinman, Effect of Suppressive DNA on CpG-Induced Immune Activation, J. Immunol, 169:5590, 2002.
M. Gürsel, D. Verthelyi, D. M. Klinman, CpG oligodeoxynucleotides stimulate human monocytes to mature into functional dendritic cells Eur. J. Immunol., 32:2617, 2002.
M. Gürsel, D. Verthelyi, I. Gursel, KJ. Ishii, DM. Klinman, Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotides, J. Leuko. Biol.,71:813, 2002.
D.M. Klinman, F. Takeshita, I. Gursel, C. Leifer, K.J. Ishii, D. Verthelyi, M. Gürsel CpG DNA: recognition by and activation of monocytes, Microbes and Infection, 4:897, 2002.
KJ. Ishii, F.Takeshita, I. Gursel, M. Gürsel, J. Conover, A. Nussenzweig, DM. Klinman, Potential role of PI3 kinases, rather than DNA-PK, in CpG DNA induced immune activation, J. Exp. Med., 196:269, 2002.
F. Takeshita, C. Leifer, İ. Gürsel, M. Gürsel, K. J. Ishii, D. M. Klinman, Cutting Edge: Role of Toll-like receptor-9 in CpG DNA induced activation of human cells. J. Immunol. 167:3555, 2001.
İ. Gürsel, M. Gürsel, K. J. Ishii, DM Klinman, Sterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotides, J. Immunol., 167:3224, 2001.
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