Mehmet SOMEL

Middle East Technical University Üniversiteler Mahallesi, Dumlupınar Bulvarı No:1 Biyolojik Bilimler, 119 06800 Çankaya Ankara/TURKEY

Office Room: 119

Tel: 0090 312 210 6460

Web: http://compevo.bio.metu.edu.tr/

Education: 2008 - Ph.D. in Biology, University of Leipzig 2003 - M.Sc. in Biotechnology, METU 2001 - B.S. in Biology, METU

Research Interest: - Human population genetics; ancient DNA. - Comparative human evolution; transcriptome evolution; evolution of aging.

Description of Research Activities: The Comparative & Evolutionary Biology team (CompEvo) studies human history and evolution using genomic and transcriptomic data. Our previous work focused on differences in gene expression timing in brain development between humans and chimpanzees that may underlie cognitive differences between these species. Our group continues working on genomic and transcriptomic variation in modern-day and ancient humans, and other primates. Our current focus is using ancient DNA to infer human demographic and biological history, and we work as part of the METU Ancient DNA and Population Genetics Laboratory.

Selected Publications: Link to full list Archaeogenetics of Late Iron Age Çemialo Sırtı, Batman: Investigating maternal genetic continuity in north Mesopotamia since the Neolithic R Yaka, A Birand, Y Yılmaz, C Caner, SC Açan, S Gündüzalp, et al. (2018) American Journal of Physical Anthropology [link] Archaeogenomic analysis of the first steps of Neolithization in Anatolia and the Aegean GM Kılınç, D Koptekin, Ç Atakuman, AP Sümer, HM Dönertaş, et al. (2017) Proc. R. Soc. B [link] Variation and functional impact of Neanderthal ancestry in Western Asia RO Taskent, ND Alioglu, E Fer, H Melike Donertas, M Somel, O Gokcumen (2017) Genome Biology and Evolution [link] Gene expression reversal toward pre-adult levels in the aging human brain and age-related loss of cellular identity HM Dönertaş, H İzgi, A Kamacıoğlu, Z He, P Khaitovich, M Somel (2017) Scientific Reports [link] The Demographic Development of the First Farmers in Anatolia GM Kılınç, A Omrak, F Özer, T Günther, AM Büyükkarakaya, E Bıçakçı, et al. (2016) Current Biology [link] Disruption of an Evolutionarily Novel Synaptic Expression Pattern in Autism X Liu, D Han, M Somel, X Jiang, H Hu, P Guijarro, N Zhang, A Mitchell, et al. (2016) PLoS Biology [link] Determining the origin of synchronous multifocal bladder cancer by exome sequencing Ö Acar, E Özkurt, G Demir, H Saraç, C Alkan, T Esen, M Somel, NA Lack (2015) BMC Cancer [link] Whole genome sequencing of Turkish genomes reveals functional private alleles and impact of genetic interactions with Europe, Asia and Africa C Alkan, P Kavak, M Somel, O Gokcumen, S Ugurlu, C Saygi, E Dal, et al. (2014) BMC Genomics [link] Heterochrony explains convergent testis evolution in primates E Saglican, E Ozkurt, H Hu, B Erdem, P Khaitovich, M Somel (2014) bioRxiv [link] Shared signatures of social stress and aging in peripheral blood mononuclear cell gene expression profiles N Snyder‐Mackler, M Somel, J Tung (2014) Aging Cell [link] Evolution of Human Longevity Uncoupled from Caloric Restriction Mechanisms G Zhao, S Guo, M Somel* and P Khaitovich* (2014) PLoS ONE [link] Transcriptomic insights into human brain evolution: acceleration, neutrality, heterochrony M Somel, R Rohlfs, X Liu (2014) Current Opinion in Genetics & Development [review] [pdf] Human brain evolution: transcripts, metabolites and their regulators M Somel, X Liu, P Khaitovich (2013) Nat Rev Neuro [review] [pdf] A scan for human−specific relaxation of negative selection reveals unexpected polymorphism in proteasome genes. Somel M, Wilson Sayres M, Jordan G, Huerta-Sanchez E, Fumagalli M, Ferrer-Admetlla A, Nielsen R. (2013) Mol Biol Evol [link] Accelerated aging-related transcriptome changes in the female prefrontal cortex. Yuan Y, Chen YP, Boyd-Kirkup J, Khaitovich P, Somel M. (2012) Aging Cell [link] Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques. Liu X*, Somel M*, Tang L*, Yan Z, Jiang X, Guo S, Yuan Y, He L, Oleksiak A, Zhang Y, Li N, Hu Y, Chen W, Qiu Z, Pääbo S, Khaitovich P. (2012) Genome Res [link] MicroRNA-driven developmental remodeling in the brain distinguishes humans from other primates. Somel M*, Liu X*, Tang L, Yan Z, Hu H, Guo S, Jiang X, Zhang X, Xu G, Xie G, Li N, Hu Y, Chen W, Pääbo S, Khaitovich P. (2011) PLoS Biol [link] MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain. Somel M*, Guo S*, Fu N*, Yan Z, Hu HY, Fu X, Yuan Y, Ning Z, Hu Y, Menzel C, Hu H, Lachmann M, Zeng R, Chen W, Khaitovich P (2010) Genome Res [link] Transcriptional Neoteny in the Human Brain. Somel M, Franz H, Yan Z, Lorenc A, Guo S, Giger T, Kelso J, Nickel B, Dannemann M, Bahn S, Webster MJ, Weickert CS, Lachmann M, Pääbo S, Khaitovich P (2009) PNAS [link] Human and chimpanzee gene expression differences replicated in mice fed different diets. Somel M*, Creely H*, Franz H, Mueller U, Lachmann M, Khaitovich P, Pääbo S. (2008) PLoS ONE 30;3(1):e1504 [link] Gene expression becomes heterogeneous with age. Somel M, Khaitovich P, Bahn S, Pääbo S, Lachmann M. (2006) Current Biology 16(10):R359-60 [pdf] *: contributed equally

Graduate program affiliation: Biology, Biochemistry, Bioinformatics, Biotechnology, Archaeometry