FACULTY OF ARTS AND SCIENCESDEPARTMENT OF BIOLOGICAL SCIENCES: BIOLOGY/MOLECULAR BIOLOGY & GENETICS


Faculty

Prof. Dr. Ufuk GÜNDÜZ

Middle East Technical University, Department of Biological Sciences, 06800 Ankara/TURKEY

Office Room: 247

Tel: +90 312 210 5183

Fax: +90 312 210 7976

E - Mail: ufukg[-at-]metu.edu.tr

Web:

Education: B.S. – M.S. in Chem.Engineering(Iowa State Univ.,USA), Ph D in Biology (METU,Ankara)


Research Interest: Cancer Molecular Biology, Biotechnology


Description of research activities: Multi-drug resistance in various cancer types, Drug targeting in cancer by nanoparticles, Bio-Hydrogen Production using photosynthetic bacteria


Selected Publications:

1- Kars, M.D., Işeri,Ö.D.,Gündüz,U., " Drug Resistant Breast Cancer Cells Overexpress ETS1 Gene", Biomedicine and Pharmacotheraphy 64, (2010) 458-462.
2-Işeri, Ö.D., Kars, M.D., Gündüz, U., "Drug Resistant MCF-7 Cells have Altered Expression Levels of ß-Tubulin Isotypes and Mutations in TUBB Gene", UHOD-Uluslararası Hematoloji-Onkoloji Dergisi 20, 2, (2010) 75-83.

3-Ekiz, H.A., Geylani, C., Gündüz, U., Baran, Y., "Nilotinib Significantly Induces Apoptosis in Imatinib Resistant K562 cells With Wild-type BCR–ABL, as Effectively as in Parental Sensitive Counterparts", Hematology 15, 1, (2010) 33-38.

4-Ozgur, E., Mars, A.E., Peksel, B., Louwerse, A., Yucel, M., Gunduz, U., Claassen, P.A.M., Eroglu, I., "Biohydrogen Production from Beet Molasses by Sequential Dark and Photofermentation", International J. of Hydrogen Energy 35, (2010) 511-517.

5-Kosova, B., Tezcanlı, B., Ekiz, H.A., Cakir, Z., Selvi, N., Dalmizrak, A., Kartal, M., Gunduz, U., Baran, Y., “Suppression of STAT5A Increases Chemotherapeutic Sensitivity in Imatinib-Resistant and Imatinib-Sensitive K562 Cells” Leukemia & Lymphoma 51, 10 (2010) 1895-1901.

6- Afşar, N., Özgür, E., Gürgan, M., Akköse, S., Yücel, M., Gündüz, U., Eroglu, E., “Hydrogen Productivity of Photosynthetic Bacteria on Dark Fermenter Effluent of Potato Steam Peels Hydrolysate”, International J. of Hydrogen Energy 36, (2010) 432-438.

7-Iseri, O.D., Kars, M.D., Arpaci, F., Atalay, C., Pak, I., Gündüz, U., “Drug resistant MCF-7 cells exhibit epithelial-mesenchymal transition gene expression pattern”, Biomedicine and Pharmacotherapy 65 , 1 (2011) 40-45

8- Dönmez, Y., Akhmetova, L., Işeri, O.D., Kars, M.D., Gündüz, U., “Effect of MDR Modulators Verapamil and Promethazine on Gene Expression Levels of MDR1 and MRP1 in Doxorubicin-Resistant MCF-7 Cells”, Cancer Chemotheraphy and Pharmacology 67, 4, (2011) 823-828.

9-Dönmez, Y., Gündüz, U., 2010. Reversal of Multidrug Resistance by Small Interfering RNA (siRNA) in Doxorubicin-Resistant MCF-7 Breast Cancer Cells.
Biomedicine and Pharmacotherapy, 65, 2 (2011) 85-89.

10- Kars, M.D., Işeri O.D., Gündüz, U., “A Microarray Based Expression Profiling of Paclitaxel and Vincristine Resistant MCF-7 Cells”, European Journal of Pharmacology, 657, 1-3 (2011) 4-9.

11- Afsar, N., Özgür, E., Gürgan, M., Akköse, S., Yücel, M., Gündüz, U., Eroglu, I., "Hydrogen Productivity of Photosynthetic Bacteria on Dark Fermenter Effluent of Potato Steam Peels Hydrolysate"., International J. of Hydrogen Energy 36, 1 (2011) 432-438.


Graduate program affiliation: Biotechnology, Biology