Erkan Kiriş

Assistant Professor


+90 (312) 210 5169

ekiris[at]metu.edu.tr

Room Z-16


EDUCATION

 Neural Development Section (Tessarollo Laboratory), Mouse Cancer Genetics Program, National Cancer Institute at Frederick, National Institutes of Health (In collaboration with US Army Medical Research Institute of Infectious Diseases — Bavari Laboratory), Frederick, MD, USA, 2009-2017

 Neuroscience Research Institute, University of California, Santa Barbara, CA, USA, 2008-2009

 Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA, USA, 2003-2008

 Faculty of Arts and Science, Department of Biology, Mugla University, Mugla, Turkey, 2000-2003

 Faculty of Education, Department of Biology, Selcuk University, Konya, Turkey, 1996-2000


AREA OF RESEARCH

Our laboratory conducts research in the field of molecular neurobiology, utilizing mouse embryonic stem cell and human induced pluripotent stem cell-derived neuronal models. Our research interests include,

i) modulation of neurotrophin signaling against neurodegenerative diseases,
ii) examining whether Trk receptor signaling and Estrogen receptor signaling work in concert, potentially in a sex-specific manner, in neuroprotection in the context of neurodegenerative conditions, and
iii) Botulinum Neurotoxin (BoNT) research and drug discovery:

a) identification of mechanism-targeted compounds to discover novel leads that can be effective against BoNT serotypes responsible for human botulism cases, using motor neuron systems,
b) elucidation of critical molecular mechanisms involved in the intoxication and/or recovery, and
c) developing stem cell based detection technologies for these toxins.


SELECTED PUBLICATIONS

Y.C. Tsai, A. Kotiya, E. Kiris, M. Yang, S. Bavari, L. Tessarollo, G.A. Oyler, A.M. Weissman (2017). The deubiquitinating enzyme VCIP135 dictates the duration of botulinum neurotoxin type A intoxication. Proceedings of the National Academy of Sciences. 114(26):E5158-E5166. doi: 10.1073/pnas.1621076114.


S. Puverel*, E. Kiris*, S. Singh, K.D. Klarmann, V. Coppola, J. Keller and L. Tessarollo (2016). RanBPM (RanBP9) regulates mouse c-Kit receptor level and is essential for normal development of bone marrow progenitor cells. Oncotarget, 2016 Dec 20;7(51):85109-85123. doi: 10.18632/oncotarget.13198. * Equal Contribution.


E. Kiris*, T. Wang*, S. Yanpallewar, S. Dorsey, J. Becker, S. Bavari, M.E. Palko, V. Coppola, and L. Tessarollo (2014). “TrkA in vivo function is negatively regulated by ubiquitination”. The Journal of Neuroscience, Mar 12;34(11):4090-8. doi: 10.1523/JNEUROSCI.4294-13.2014. *Equal Contribution.


E. Kiris, J. E. Nuss, J. C. Burnett, K. P. Kota, D. C. Koh, L. M. Wanner, E. Torres-Melendez, R. Gussio, L. Tessarollo, and S. Bavari (2011). Embryonic stem cell derived motoneurons provide a highly sensitive cell culture model for botulinum neurotoxin studies, with implications for high-throughput drug discovery. Stem Cell Research, 6, pp 195-205, doi: 10.1016/j.scr.2011.01.002.


E. Kiris, D. Ventimiglia, M. R. Gaylord, M.E. Sargin, A. Altinok, K. Rose, B.S. Manjunath, M. A. Jordan, L. Wilson and S. C. Feinstein (2011). Combinatorial Tau Pseudophosphorylation: Markedly different regulatory effects on microtubule assembly and dynamic instability than the sum of the individual parts. Journal of Biological Chemistry, 286, 14257-14270, doi: 10.1074/jbc.M111.219311.


Last Updated:
12/10/2019 - 18:00