Mehmet Somel

Associate Professor


+90 (312) 210 6465

msomel[at]metu.edu.tr

Room 248


EDUCATION

 Rasmus Nielsen Lab, UC Berkeley, CA, USA, 2011 - 2013

 Philipp Khaitovich lab, CAS-MPG Partner Institute for Computational Biology (PICB), Shanghai, People's Republic of China, 2008 - 2011

 Faculty of Life Sciences, University of Leipzig / Max-Planck Institute for Evolutionary Anthropology, Leipzig, Germany, 2004-2008

 Department of Biotechnology, METU, Ankara, 2001-2003

 Department of Biology, METU, Ankara, 1996-2001


AREA OF RESEARCH

We address questions on human history and evolution using genomic data. This includes ancient DNA analyses (archaeogenomics) of humans and domestic animals and population genomics of modern-populations. We work as part of the METU/Hacettepe Archaeogenomics Laboratory. We also use comparative genomic and transcriptomic data to address questions on two main processes: evolution and aging. We have previously studied molecular mechanisms of brain aging, evolutionary and molecular dynamics of aging, and adaptive and non-adaptive evolution in diverse organisms, including primates and fish.


SELECTED PUBLICATIONS

Turan ZG, Parvizi P, Dönertaş HM, Tung J, Khaitovich P, Somel M. Molecular footprint of Medawar's mutation accumulation process in mammalian aging. Aging Cell. 2019 Aug;18(4):e12965. doi: 10.1111/acel.12965


Kılınç GM, Koptekin D, Atakuman Ç, Sümer AP, Dönertaş HM, Yaka R, Bilgin CC, Büyükkarakaya AM, Baird D, Altınışık E, Flegontov P, Götherström A, Togan İ, Somel M. Archaeogenomic analysis of the first steps of Neolithization in Anatolia and the Aegean. Proceedings of the Royal Society B: Biological Sciences 2017 Nov 29;284(1867). pii: 20172064. doi: 10.1098/rspb.2017.2064


Dönertaş HM, İzgi H, Kamacıoğlu A, He Z, Khaitovich P, Somel M. Gene expression reversal toward pre-adult levels in the aging human brain and age-related loss of cellular identity. Scientific Reports. 2017 Jul 19;7(1):5894. doi: 10.1038/s41598-017-05927-4


Kılınç GM, Omrak A, Özer F, Günther T, Büyükkarakaya AM, Bıçakçı E, Baird D, Dönertaş HM, Ghalichi A, Yaka R, Koptekin D, Açan SC, Parvizi P, Krzewińska M, Daskalaki EA, Yüncü E, Dağtaş ND, Fairbairn A, Pearson J, Mustafaoğlu G, Erdal YS, Çakan YG, Togan İ, Somel M, Storå J, Jakobsson M, Götherström A. The Demographic Development of the First Farmers in Anatolia. Current Biology. 2016 Oct 10;26(19):2659-2666. doi: 10.1016/j.cub.2016.07.057


Somel M, Liu X, Khaitovich P. Human brain evolution: transcripts, metabolites and their regulators. Nature Reviews Neuroscience. 2013 Feb;14(2):112-27. doi: 10.1038/nrn3372. Epub 2013 Jan 17. Review


Last Updated:
02/10/2019 - 10:18