Müslüm İlgü

Assistant Professor


+90 (312) 210 6464

ilgu[at]metu.edu.tr

Room 123


EDUCATION

 Aptalogic Inc., Ames, IA, 2014-(ongoing)

 Molecular Express Inc., Ames, IA, 2013-2014

 The Ames Laboratory, Ames, IA, 2012-2013

 Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, 2012

 Department of Biology, Middle East Technical University, 2005


AREA OF RESEARCH

Our research group is interested in characterization of aptamer ligand interactions by both computational and biochemical means. To achieve this, we combine diverse multidisciplinary approaches and currently involved in aptamer selection for biomarkers, viruses and membrane proteins that can later be used to diagnose and/or treat cancer and other diseases. In our studies, we employ computational modeling, aptamer selection and biophysical characterization, isothermal titration calorimetry, fluorescence measurements and cloning as well as in vivo aptamer expression platforms. Our overall goal is to use nucleic acid aptamers for treating diseases, detecting biomarkers in biological matrices and combining them in sensing platforms in collaboration with electrical, chemical and mechanical engineers.


SELECTED PUBLICATIONS

Muslum Ilgu, Rezzan Fazlioglu, Meric Ozturk, Yasemin Ozsurekci, Marit Nilsen-Hamilton (2019). Aptamers for Diagnostics with Applications for Infectious Diseases. Recent Advances in Analytical Chemistry, Muharrem Ince and Olcay Kaplan Ince, IntechOpen, DOI: 10.5772/intechopen.84867.


Muslum Ilgu, and Nilsen-Hamilton M (2016). Aptamers in analytics. Analyst 141 (5), 1551-1568. Critical Review*


Muslum Ilgu, Judhajeet Ray, Tianjiao Wang, Ivan M. Geraskin, Lee Bendickson, George A. Kraus and Marit Nilsen-Hamilton (2016). Light-up and FRET aptamer reporters; evaluating their applications for imaging transcription in eukaryotic cells. Methods 98, 26-33.


Ilchung Shin*, Judhajeet Ray*, Vinayak Gupta, Muslum Ilgu, Hans Eirik Haarberg, Jonathan Beasely, Lee Bendickson, Samir Mehanovic, George A. Kraus and Marit Nilsen-Hamilton (2014). Live-cell Imaging of Pol II Promoter Activity to Monitor Gene Expression with RNA reporters. Nucleic Acid Research, gku297 (*co-first authors).


Muslum Ilgu, Bruce D. Fulton, Ragothaman M Yennamalli, Monica H. Lamm, Taner Z. Sen and Marit Nilsen-Hamilton (2014). An adaptable pentaloop Defines a Robust Neomycin-B RNA Aptamer with Conditional Ligand-Bound Structures. RNA 20 (6), 815-824.


Last Updated:
08/10/2019 - 13:30