Orhan Adalı

Professor


+90 (312) 210 5182

bioorhan[at]metu.edu.tr

Room 142


EDUCATION

 NIH, Laboratory of Signal Transduction, Research Triangle Park, North Carolina, USA, 1997

 Department of Biochemistry, Middle East Technical University, Turkey, 1983-1988

 Department of Biology, Middle East Technical University, Turkey, 1980-1983

 Department of Biology, Middle East Technical University, Turkey, 1975-1980


AREA OF RESEARCH

The characterization of the microsomal enzyme systems metabolizing drugs, environmental chemicals and carcinogens; The clarification of the possible role of flavin monooxygenases in structure and function by employing molecular biology and genetic techniques; Cytochrome P450 (CYP) and flavin monooxygenase (FMO) specific reactions;  Polimorphism (Genotyping and phenotyping) of CYP and FMO isoenzymes, paraoxanase, TPMT in human with different disorders; diabetes, stroke, MS and cancer (leukemia); Vitamin D and MS relation,  Pharmacogenetic.


SELECTED PUBLICATIONS

Esra Bilgin, Birsen Can Demirdöğen, Aysun Türkanoğlu Özçelik, Şeref Demirkaya, Orhan Adalı “Association analysis of Glutathione S-transferase omega-1 and omega-2 genetic polymorphisms and ischemic stroke risk in a Turkish population” Neurological Research, Vol. 41, No: 2, 118-124, 2019. https://doi.org/10.1080/01616412.2018.1544385


Sena Gjota-Ergin, Çiğdem Gökçek-Saraç¸ Orhan Adalı, Ewa Jakubowska-Doğru “Relationship between the hippocampal expression of selected cytochrome P450 isoforms and the animal performance in the hippocampus-dependent learning task” Neuroscience Letters, Vol. 673, No: 4, 104-110, 2018. https://doi.org/10.1016/j.neulet.2018.02.059


S. Karakurt, O. Adalı “Tannic Acid Inhibited Proliferation, Metastasis, Invasion of Prostate Cancer and Modulate Drug Metabolizing Cytochrome P450 and Antioxidant Enzymes” Anti-Cancer Agents in Medicinal Chemistry, Vol. 16, No. 6, 781-789, (DOI: 10.2174/1871520616666151111115809), 2016.


S. Karakurt, A. Semiz, G. Celik, A. M. Gencler-Ozkan, A. Sen, O. Adalı “Epilobium hirsutum alters xenobiotic metabolizing CYP1A1, CYP2E1, NQO1 and GPx activities, mRNA and protein levels in rats” Pharmaceutical Biology, 51 (5), 650-658, 2013.


E. Arınç, Ş. Arslan, O. Adalı “Differential effects of diabetes on CYP2E1 and CYP2B4 proteins and associated drug metabolizing enzyme activities in rabbit liver” Archives of Toxicology, 79(8), 427-433, 2005.


Last Updated:
02/10/2019 - 17:50