EDUCATION
Ph.D
1998-2002
Department of Food Science, University of Leeds, Leeds, United Kingdom
M.Sc
1997-1998
Department of Food Science, University of Leeds, Leeds, United Kingdom
B.Sc
1994-1997
Department of Physiology, University of Calcutta, Kolkata, West Bengal, India
RESEARCH SUMMARY
The primary focus of the laboratory is on pathways regulating metabolism in cancer cells. Deregulated metabolism of proteins, lipids, and fatty acids is increasingly being appreciated as a hallmark of cancer. The signaling pathways regulating these metabolic changes, therefore, need to be examined to better understand the metabolic deregulations and novel targets for drug development. Additionally, starving cancer cells of specific nutrients and amino acids can also increase their sensitivity the chemotherapy. Using colorectal cancer as a model, our laboratory systematically focuses on pathways related to lipid and carbohydrate metabolism and the role played by these bioactive compounds in the regulation of inflammatory pathways.
SELECTED PUBLICATIONS
Tunçer S, Çolakoğlu M, Ulusan S, Ertaş G, Karasu Ç, Banerjee S. Evaluation of colloidal platinum on cytotoxicity, oxidative stress and barrier permeability across the gut epithelium. Heliyon. 2019 Mar 21;5(3):e01336. doi: 10.1016/j.heliyon.2019.e01336.
Tunçer S, Gurbanov R, Sheraj I, Solel E, Esenturk O, Banerjee S. Low dose dimethyl sulfoxide driven gross molecular changes have the potential to interfere with various cellular processes. Scientific Reports. 2018 Oct 4;8(1):14828. doi: 10.1038/s41598-018-33234-z.
Çolakoğlu M, Tunçer S, Banerjee S. Emerging cellular functions of the lipid metabolizing enzyme 15-Lipoxygenase-1. Cell Proliferation. 2018 Oct;51(5):e12472. doi: 10.1111/cpr.12472.
Taşkoparan B., Seza E.G., Demirkol S., Tunçer S., Stefek M., Gure A.O., Banerjee S. Opposing roles of the aldo-keto reductases AKR1B1 and AKR1B10 in colorectal cancer. Cellular Oncology, 2017. 40(6):563-578.
Tunçer S., Keşkuş A.G., Çolakoğlu, M., Çimen, I., Yener C., Konu, O., Banerjee, S. 15-Lipoxygenase-1 re-expression in colorectal cancer alters endothelial cell features through enhanced expression of TSP-1 and ICAM-1. Cellular Signalling, 2017, 39:44-54
