Nihal Terzi Çizmecioğlu

Assistant Professor


+90 (312) 210 5181

nterzi[at]metu.edu.tr

Room 244


EDUCATION

 Boston Children's Hospital, Dept. of Hematology/Oncology, Boston MA USA, 2011-2016

 Harvard University, Dept. of Biological Chemistry and Molecular Pharmacology, Cambridge MA USA, 2005-2011

 Bilkent University, Dept. of Molecular Biology and Genetics, Ankara Turkey, 2001-2005


AREA OF RESEARCH

We are interested in the role of chromatin in regulating cell fate decisions. During embryonic development, the zygote undergoes numerous cell division and differentiation events to eventually form the embryo. The gene expression processes accompanying embryonic development are regulated with high spatial and temporal precision. Chromatin environment affects the accessibility and the activity of target genes. Using embryonic stem cell lineage commitment as an in vitro model for cell fate changes, we are working on the role of chromatin on gene expression regulation. We aim to identify key gene expression pathways and mechanisms using molecular, transcriptomic and proteomic approaches. Complementing wet lab work, we are also invested in bioinformatic approaches analyzing and crossreferencing our high-throughput data.


SELECTED PUBLICATIONS

Church VA, Pressman S, Isaji M, Truscott M, Cizmecioglu NT, Buratowski S, Frolov MV, Carthew RW (2017). Microprocessor Recruitment to Elongating RNA Polymerase II Is Required for Differential Expression of MicroRNAs. Cell Rep 20 (13), 3123-3134.


Terzi, N., Churchman, L. S., Vasiljeva, L., Weissman, J., and Buratowski, S. (2011). H3K4 trimethylation by Set1 promotes efficient termination by the Nrd1-Nab3-Sen1 pathway. Mol Cell Biol 17, 3569-83.


Vasiljeva, L., Kim, M., Terzi, N., Soares, L. M., and Buratowski, S. (2008). Transcription termination and RNA degradation contribute to silencing of RNA polymerase II transcription within heterochromatin. Mol Cell 29, 313-323.


Seli, E., Lalioti, M. D., Flaherty, S. M., Sakkas, D., Terzi, N., and Steitz, J. A. (2005). An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos. Proc Natl Acad Sci U S A 102, 367-372.


Last Updated:
08/10/2019 - 21:13