EDUCATION
AREA OF RESEARCH
Research is focused on innate immune responses mediated by host pattern recognition receptors (PRRs). Active research topics include immunotherapeutic/vaccine adjuvant applications of PRR ligands, immunomodulatory applications of commensal bacteria-derived membrane vesicles, anti-Leishmanial immunity and leishmania-exosome based vaccination. We also conduct collaborative work with clinical immunologists to study the mechanisms contributing to disease pathogenesis in primary immunodeficiencies.
SELECTED PUBLICATIONS
Gul E, Sayar EH, Gungor B, Eroglu FK, Surucu N, Keles S, Guner SN, Fındık S, Alpdündar E, Ayanoglu IC, Kayaoglu B, Geçkin BN, Sanli HA, Kahraman T, Yakicier C, Muftuoglu M, Oguz B, Cagdas Ayvaz DN, Gursel I, Ozen S, Reisli I, Gursel M. Type I IFN related NETosis in Ataxia Telangiectasia and Artemis deficiency. J Allergy Clin Immunol. 2018;142(1):246-257. doi: 10.1016/j.jaci.2017.10.030.
Yildiz S, Alpdundar E, Gungor B, Kahraman T, Bayyurt B, Gursel I, Gursel M. Enhanced immunostimulatory activity of cyclic dinucleotides on mouse cells when complexed with a cell-penetrating peptide or combined with CpG. Eur J Immunol. 45(4):1170-9 2015; doi: 10.1002/eji.201445133.
Gungor B, Yagci FC, Tincer G, Bayyurt B, Alpdundar E, Yildiz S, Ozcan M, Gursel I, Gursel M. CpG ODN nanorings induce IFNα from plasmacytoid dendritic cells and demonstrate potent vaccine adjuvant activity. Sci Transl Med. 2014; 6(235):235ra61. doi: 10.1126/scitranslmed.3007909
Yáñez-Mó M, Siljander PR, Andreu Z, Zavec AB, Borràs FE, Buzas EI, Buzas K, Casal E, Cappello F, Carvalho J, Colás E, Cordeiro-da Silva A, Fais S, Falcon-Perez JM, Ghobrial IM, Giebel B, Gimona M, Graner M, Gursel I, Gursel M, Heegaard NH, Hendrix A, Kierulf P, Kokubun K, Kosanovic M, Kralj-Iglic V, Krämer-Albers EM, Laitinen S, Lässer C, Lener T, Ligeti E, Linē A, Lipps G, Llorente A, Lötvall J, Manček-Keber M, Marcilla A, Mittelbrunn M, Nazarenko I, Nolte-'t Hoen EN, Nyman TA, O'Driscoll L, Olivan M, Oliveira C, Pállinger É, Del Portillo HA, Reventós J, Rigau M, Rohde E, Sammar M, Sánchez-Madrid F, Santarém N, Schallmoser K, Ostenfeld MS, Stoorvogel W, Stukelj R, Van der Grein SG, Vasconcelos MH, Wauben MH, De Wever O. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles. 2015; 14;4:27066. doi: 10.3402/jev.v4.27066.
Gungor B, Adiguzel E, Gursel I, Yilmaz B, Gursel M. Intestinal Microbiota in Patients with Spinal Cord Injury. PLoS One. 2016;11(1):e0145878. doi: 10.1371/journal.pone.0145878