EDUCATION
AREA OF RESEARCH
Our research has primarily focused on molecular mechanisms underlying protein thermostability. We perform functional, structural and regulatory analyses of molecular machines, such as the proteasome and molecular chaperonines, specifically small heat-shock proteins. Our work also aims at improving the stability and activity of enzymes with potential medical uses through rational design and using molecular chaperones. Furthermore, we investigate the molecular basis of stress response in thermoacidophilic archaea, using Thermoplasma volcanium as the model organism.
SELECTED PUBLICATIONS
Aygar, G., Kaya, M., Özkan, N., Kocabıyık, S., Volkan, M, 2015. Preparation of silica encoated cobalt ferritin magnetic nanoparticles for the purification of histidine tagged proteins. Journal of Physics and Chemistry of Solids, 87:64-71.
Kocabıyık, S., S. Aygar, 2012. Improvement of protein stability and enzyme recovery under stress conditions by using a small HSP (tpv-HSP 14.3) from Thermoplasma volcanium. Process Biochemistry, 47:1676-1683.
Kocabıyık, S., Özdemir, İ., Zwickl, P., Özdoğan, S. Molecular Cloning and co-expression of Thermoplasma volcanium proteasome subunit genes. Protein Expression and Purification, 73 : 223-230 (2010).
Kocabıyık, S, 2009. Essential structural and functional features of small heat shock proteins in molecular chaperoning process. Protein and Peptide Letters, 16 (6): 613-622.
Kocabıyık, S., B. Demirok, 2009. Cloning and Overexpression of a Thermostable Signal Peptide Peptidase (SppA) from Thermoplasma volcanium GSS1 in E.coli. Biotechnology Journal, 4: 1055-1065.