Division of Biology and Biological Engineering, California Institute of Technology, Los Angeles, CA, USA
Department of Microbiology, University of Tennessee, Knoxville, TN, USA
Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN, USA
Department of Biological Sciences, Middle East Technical University, Ankara, Turkiye
Department of Biological Sciences, Middle East Technical University, Ankara, Turkiye With a Minor in Chemistry (1995-1997)
Currently, our research focused on the identification of protein-protein interactions by quantitative Förster resonance energy transfer (FRET) measurements as well as by fluorescence intensity ratio (FIR) analysis in live cells. We are interested in G-protein Coupled Receptor (GPCR) dimerization and the effects of post-translational modifications and ligand interactions on receptor dimerization.
Research Interest: Membrane proteins, Protein-protein interactions, GPCRs, nAChRs, Fluorescence proteins, Confocal microscopy, Total Internal Reflection Fluorescence microscopy, FRET, HPLC, Mass spectrometry, MALDI-TOF, protein purification, Photo affinity cross-linking
Cevheroğlu, O., Murat, M., Mingu-Akmete, S., & Son, Ç. D. (2021). Ste2p Under the Microscope: the Investigation of Oligomeric States of a Yeast G Protein-Coupled Receptor. The journal of physical chemistry. B, 125(33), 9526–9536. doi: 10.1021/acs.jpcb.1c05872
Aydın, A. D., Altınel, F., Erdoğmuş, H., & Son, Ç. D. (2021). Allergen fragrance molecules: a potential relief for COVID-19. BMC complementary medicine and therapies, 21(1), 41. doi: 10.1186/s12906-021-03214-4
Cevheroğlu, O., Becker, J. M., & Son, Ç. D. (2017). GPCR-Gα protein precoupling: Interaction between Ste2p, a yeast GPCR, and Gpa1p, its Gα protein, is formed before ligand binding via the Ste2p C-terminal domain and the Gpa1p N-terminal domain. Biochimica et biophysica acta. Biomembranes, 1859(12), 2435–2446. doi: 10.1016/j.bbamem.2017.09.022
Cevheroğlu, O., Kumaş, G., Hauser, M., Becker, J. M., & Son, Ç. D. (2017). The yeast Ste2p G protein-coupled receptor dimerizes on the cell plasma membrane. Biochimica et biophysica acta. Biomembranes, 1859(5), 698–711. doi: 10.1016/j.bbamem.2017.01.008
Son, C. D., Moss, F. J., Cohen, B. N., & Lester, H. A. (2009). Nicotine normalizes intracellular subunit stoichiometry of nicotinic receptors carrying mutations linked to autosomal dominant nocturnal frontal lobe epilepsy. Molecular pharmacology, 75(5), 1137–1148. doi: 10.1124/mol.108.054494
For the complete list of publications from Çağdaş Devrim Son, please click here.