EDUCATION
Ph.D
1986-1991
University of California-Davis, Davis, CA, USA
Ph.D
1981-1987
Graduate School of Health Sciences, Ankara University, Ankara, Turkiye
B.Sc
1975-1980
Faculty of Veterinary Medicine, Ankara University, Ankara, Turkiye
RESEARCH SUMMARY
Our research interest is directed at the understanding of the molecular mechanisms of estrogen hormone action. The flow of estrogen information is primarily conveyed by the transcription factors, estrogen receptors (ERs) α and β. The estrogen-bound ERs primarily mediate many nuclear events that result in gene expressions. Utilizing a multidisciplinary approach that includes biochemistry, molecular, cellular, and tumor biology, we aim to define how estrogen-mediated gene expressions result in changes in phenotypical features of cells.
SELECTED PUBLICATIONS
Ayaz G, Yasar P, Olgun C E, Karakaya B, Kars G, Razizadeh N, Yavuz K, Turan G, Muyan M. 2019, Dynamic transcriptional events mediated by estrogen receptor alpha. Frontiers In Bioscience, Landmark, 24, 245-276.
Yaşar P, Ayaz G, User SD, Güpür G & Muyan M. 2017, Molecular Mechanism of Estrogen-Estrogen Receptor Signaling. Reproductive Medicine & Biology, 16: 4–20, doi: 10.1002/rmb2.12006.
Yaşar P, Ayaz G & Muyan M. 2017, Estradiol-Estrogen Receptor α Mediates the Expression of the CXXC5 Gene through the Estrogen Response Element-Dependent Signaling Pathway. Scientific Reports, 6, 37808; doi: 10.1038/srep37808.
Muyan M, Güpür G, Yaşar P, Ayaz G, User SD, Kazan HH and Huang Y. 2015, Modulation of Estrogen Response Element-Driven Gene Expressions and Cellular Proliferation with Polar Directions by Designer Transcription Regulators. PLoS ONE 10(8): e0136423. doi: 10.1371/journal.pone.0136423.
Nott SN, Huang Y, Li X, Fluharty B, Qui X, Welshons WV, Yeh S, Muyan M. 2009, Genomic Responses from the Estrogen Responsive Element-Dependent Signaling Pathway Mediated by ERalpha are Required to Elicit Cellular Alterations. J Biol Chem. 284:15277-15288.
