Parlar Foundation Awards for 2023
Assist. Prof. Ahmet Acar
|Web of Science Researcher ID: ABI-3298-2020
|Scopus Author ID: 57212498766
Assist Prof. Ahmet Acar with his Precision Medicine and Drug Resistance in Cancer Laboratory aims to understand the underlying mechanisms of drug resistance in cancer. Our goal is to study how cancers evolve and develop resistance to therapies. We are interested in developing quantitative in vitro 2D/3D co-culture systems with stromal fibroblasts. We leverage single-cell barcoding and next-generation sequencing technologies to delineate actionable mechanisms of drug resistance. To better address patient-specific drug resistance, we generate ex vivo Patient-Derived Organoids (PDOs) as a preclinical model system. Lastly, we are working on developing and optimizing deep learning models for histopathological WSIs to enable the acquisition, management, and extraction of the information that is crucial to decision-making processes in cancer.